Bioware Biological Products
Caliper currently offers oncology cell lines (Bioware, Bioware Ultra) covering a range of cancer models including Breast, Colorectal, Prostate, Lung as well as Lymphoma. These cells are bright enough to measure tumor growth way before the tumors are palpable, allowing a researcher to start collecting data at time points impossible with traditional micrometer measurements. The 4T1-luc2 cell line expresses up to 6500 photons/sec/cell, allowing you to detect a single cell non-invasively in vivo Bioware Ultra cell lines are optimal for studying a variety of xenograft models including orthotopic models in mice. All our cell lines meet the highest standards and are confirmed pathogen free. The in vitro growth rates of these cell lines are similar to their parental lines and the stability of reporter expression is tested for a minimum of four weeks.
Bioware Ultra Green and Bioware Ultra Red are dual labeled cell lines expressing luciferase and fluorescent protein (tdTomato or GFP) allowing you to monitor tumor growth in vivo with luciferase and ex vivo analysis like immunohistochemistry with the fluorescent protein. Caliper currently offers dual labeled cell lines in breast, gastric and bladder cancer models.
Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. Caliper's bioluminescent infectious disease light producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers, e.g., lung, sepsis, meningitis, GI, and biofilm infections. When used with a Caliper IVIS® Imaging System, models using light producing microorganisms allow the course of an infection to be monitored as the bacteria expand and migrate to different tissues in the animal, simply by imaging the bioluminescent signal detected from infection sites within the animal. Anti-infective drugs may then be used to treat the infections and their effectiveness can be determined by the change in the bioluminescent signal. Caliper offers a range of relative Gram positive and Gram negative pathogenic bacteria expressing bacterial luciferase.